Novel acyclic nucleoside phosphonate analogues with potent anti-hepatitis B virus activities.
نویسندگان
چکیده
Novel acyclic nucleoside phosphonates with a pyrimidine base preferentially containing an amino group at C-2 and C-4 and a 2-(phosphonomethoxy)ethoxy or (R)-2-(phosphonomethoxy)propoxy group at C-6 selectively inhibit the replication of wild-type and lamivudine-resistant hepatitis B viruses. The activity of the most potent compounds was comparable to that of adefovir.
منابع مشابه
The acyclic nucleoside phosphonate analogues, adefovir, tenofovir and PMEDAP, efficiently eliminate banana streak virus from banana (Musa spp.).
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 49 3 شماره
صفحات -
تاریخ انتشار 2005